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Racela A Jr, Azarnoff D, Svoboda D () Mitochondrial cavitation and hypertrophy in rat adrenal cortex due to aminoglutethimide. Lab Invest –60 PubMed Google Scholar Russfield AB () Pathology of the endocrine glands, ovary and testis of rats and by: 5. Racela A Jr, Azarnoff D, Svoboda D () Mitochondrial cavitation and hypertrophy in rat adrenal cortex due to aminoglutethimide. Lab Invest 52–60 PubMed Google Scholar Santen RJ, Henderson IC () A comprehensive guide to the therapeutic use of aminoglutethimide, Pharmanual by: 5. Chronic stress exposure commonly increases adrenal weight, but it is not known to what extent this growth is due to cellular hyperplasia or hypertrophy and whether it is subregion specific. Figure 4 Adrenal gland, Cortex - Hyperplasia in a female Sprague-Dawley rat from a chronic study (higher magnification of Figure 3). The cells in this hyperplastic lesion (H) are smaller and more closely packed than those in the adjacent normal cortex. Figure 5 Adrenal gland, Cortex - Hyperplasia in a female F/N rat from a. 2.
Adrenal cortical changes of hyperplasia and hypertrophy associated with stress are diffuse and bilateral, in contrast to focal adrenal cortical hypertrophy which is an incidental or background. Furthermore, adrenal hyperplasia and hypertrophy is known to be caused by powerful stimulation of the adrenal glands throughout delayed stress conditions [41,42]. Andrew W. Suttie, Catherine Sutcliffe, in Boorman's Pathology of the Rat (Second Edition), Hypertrophy. Hypertrophy may be bilateral and diffuse or focal. Bilateral diffuse hypertrophy is usually caused by increased secretion of ACTH; when associated with increased adrenal weight and obviously increased thickness of the cortex, it is usually diagnosed as diffuse cortical hypertrophy. Benign Adrenal Tumors. Different types of benign, or noncancerous, adrenal tumors prove a frequent cause of enlargement of the gland. Adrenal adenomas remain the most common type of benign adrenal tumors, representing over 50 percent of adrenal masses. Uncommon benign adrenal tumors include adrenal cysts and lipomas, or fat-derived tumors.
Insulin sensitizing approaches, including diet/exercise, metformin, thiazolidinediones, bariatric surgery, Ashwagandha root, Vitamin D replacement, and liraglutide can eliminate the need to use corticosteroids in the treatment of non-classical adrenal hyperplasia and valproate/anti-psychotic induced/unmasked adrenal hyperplasia due to The tight regulation of cell growth and division within an organ is essential for the development and maintenance of correct structure and function. Perturbations of renal growth occurring either developmentally or following injury to mature renal cells contribute to the abnormalities observed in a wide range of diseases. The changes in growth are increasingly recognized. Adrenal medullary hyperplasia and pheochromocytomas occur frequently in laboratory rats, both in the courseof aging and in response to prolonged administration of a variety of drugs and other. Cardiac enlargement is also observed with maternal Cushing's disease (19), and with highdose steroid treatment in infants with congenital adrenal hyperplasia (3, 52). We have used an ovine model.